Welsh School of Pharmacy, Cardiff University, Cardiff, UK.
Skin Pharmacol Physiol. 2010;23(2):113-6. doi: 10.1159/000265682. Epub 2009 Dec 14.
BACKGROUND/AIMS: The potential of pre-treating skin with Aloe vera juice as a penetration enhancer was evaluated in vitro using ketoprofen as model permeant.
To excised porcine skin mounted in Franz diffusion cells was applied either: (1) commercial Aloe vera; (2) commercial Aloe vera followed by massaging; (3) previously boiled commercial Aloe vera; (4) water (negative control); (5) tea tree oil (positive control). After 1 h, the pre-treatment was removed and the skin dosed with a saturated solution of ketoprofen in polyethylene glycol 400; the appearance of drug in the receptor phase was then monitored by HPLC.
No statistically significant differences in the transdermal delivery of ketoprofen were observed between water and all the Aloe vera pre-treatments (p > 0.05). The tea tree oil pre-treatment was significantly different to all others (p < 0.05).
Aloe vera appears to have no value as a penetration enhancer when used as a pre-treatment, although the data indirectly support the mechanism of action proposed previously, work when used 'within-vehicle'. Handling household products containing Aloe vera appears not to leave the user at elevated risk of subsequent absorption of exogenous chemicals.
背景/目的：本研究旨在评估预先使用芦荟汁处理皮肤作为渗透增强剂的潜力，以酮洛芬为模型渗透物进行体外研究。
将离体猪皮固定在 Franz 扩散池中，分别应用：（1）市售芦荟；（2）市售芦荟后按摩；（3）预先煮沸的市售芦荟；（4）水（阴性对照）；（5）茶树油（阳性对照）。1 小时后，去除预处理液，在皮肤表面涂抹饱和的酮洛芬聚乙二醇 400 溶液；然后通过 HPLC 监测药物在受体相中的出现情况。
水和所有芦荟预处理之间，酮洛芬的经皮传递没有统计学上的显著差异（p > 0.05）。茶树油预处理与其他所有预处理均有显著差异（p < 0.05）。
作为预处理，芦荟似乎没有作为渗透增强剂的价值，尽管数据间接支持先前提出的作用机制，在“载体中”使用时有效。使用含有芦荟的家用产品似乎不会使使用者面临随后吸收外源性化学物质的风险增加。
