Fox Lizelle T, Gerber Minja, du Preez Jan L, du Plessis Jeanetta, Hamman Josias H
Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
J Pharm Pharmacol. 2015 Jan;67(1):96-106. doi: 10.1111/jphp.12311. Epub 2014 Sep 5.
The aim of this study was to investigate the in-vitro permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound.
The permeation studies were conducted across excised female abdominal skin in Franz diffusion cells, and the delivery of ketoprofen into the stratum corneum-epidermis and epidermis-dermis layers of the skin was investigated using a tape-stripping technique.
A. vera gel showed the highest permeation-enhancing effect on ketoprofen (enhancement ratio or ER = 2.551) when compared with the control group, followed by A. marlothii gel (ER = 1.590) and A. ferox whole-leaf material (ER = 1.520). Non-linear curve fitting calculations indicated that the drug permeation-enhancing effect of A. vera gel can be attributed to an increased partitioning of the drug into the skin, while A. ferox whole leaf modified the diffusion characteristics of the skin for ketoprofen. The tape stripping results indicated that A. marlothii whole leaf delivered the highest concentration of the ketoprofen into the different skin layers.
Of the selected aloe species investigated, A. vera gel material showed the highest potential as transdermal drug penetration enhancer across human skin.
本研究旨在以酮洛芬作为标记化合物，研究库拉索芦荟、莫氏芦荟和好望角芦荟凝胶及全叶材料的体外渗透增强作用。
在Franz扩散池中对切除的女性腹部皮肤进行渗透研究，并采用胶带剥离技术研究酮洛芬在皮肤角质层-表皮层和表皮-真皮层的释放情况。
与对照组相比，库拉索芦荟凝胶对酮洛芬的渗透增强作用最高（增强率或ER = 2.551），其次是莫氏芦荟凝胶（ER = 1.590）和好望角芦荟全叶材料（ER = 1.520）。非线性曲线拟合计算表明，库拉索芦荟凝胶的药物渗透增强作用可归因于药物在皮肤中分配的增加，而好望角芦荟全叶改变了皮肤对酮洛芬的扩散特性。胶带剥离结果表明，莫氏芦荟全叶将最高浓度的酮洛芬输送到不同的皮肤层。
在所研究的选定芦荟品种中，库拉索芦荟凝胶材料作为跨人皮肤的透皮药物渗透增强剂显示出最高潜力。
