Beelen D W, Quabeck K, Mahmoud H K, Sayer H G, Kraft J, Graeven U, Grosse-Wilde H, Quast U, Schaefer U W
Klinik und Poliklinik für Knochenmarktransplantation, Universitätsklinikum Essen.
Dtsch Med Wochenschr. 1991 Mar 15;116(11):401-10. doi: 10.1055/s-2008-1063625.
Over a 10-year period 120 patients (58 women, 62 men; median age 33 [14-53] years) with acute myeloid leukaemia were treated by allogenic (n = 90) or autologous bone marrow transplantation to maintain remission. After a median observation time of 41 (11-126) months 64 patients (53%) remain alive without recurrence of leukaemia. Ten years after allogenic transplantation performed during the first complete remission the probability of disease-free survival is 50 +/- 8%, as compared with 50 +/- 9% at 4.5 years after autologous transplantation. Significant factors influencing disease-free survival after allogenic transplantation during the first complete remission were the time interval up to the onset of remission and the length of the remission before transplantation. The chance of disease-free survival after allogenic transplantation in the second complete remission does not so far differ from the results achieved by transplantation in the first complete remission. The risk of recurrence after autologous transplantation in the first complete remission (47 +/- 10%) is significantly higher than that following allogenic transplantation (18 +/- 10%, P less than 0.0001). Acute graft versus host reactions occurred in 16% and chronic reactions in 36% of patients after allogenic transplantation. The mortality was 38% after allogenic transplantation and 7% after autologous transplantation.
在10年期间，120例急性髓性白血病患者（58例女性，62例男性；中位年龄33[14 - 53]岁）接受了异基因（n = 90）或自体骨髓移植以维持缓解状态。经过中位观察时间41（11 - 126）个月后，64例患者（53%）存活且白血病未复发。在首次完全缓解期进行异基因移植10年后，无病生存率为50±8%，而自体移植4.5年后为50±9%。影响首次完全缓解期异基因移植后无病生存的重要因素是至缓解开始的时间间隔以及移植前缓解的持续时间。目前，第二次完全缓解期异基因移植后的无病生存机会与首次完全缓解期移植所取得的结果并无差异。首次完全缓解期自体移植后的复发风险（47±10%）显著高于异基因移植后（18±10%，P＜0.0001）。异基因移植后，16%的患者发生急性移植物抗宿主反应，36%的患者发生慢性反应。异基因移植后的死亡率为38%，自体移植后的死亡率为7%。
