循环微小RNA与癌症诊断

Circulating miRNA and cancer diagnosis.

作者信息

Tie Yi, Liu BinDong, Fu HanJiang, Zheng XiaoFei

机构信息

Beijing Institute of Radiation Medicine, Bejing, China.

出版信息

Sci China C Life Sci. 2009 Dec;52(12):1117-22. doi: 10.1007/s11427-009-0158-5. Epub 2009 Dec 17.

DOI:10.1007/s11427-009-0158-5

PMID:20016968

Abstract

miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area.

摘要

微小RNA（miRNA）是一类具有调控功能的小RNA分子，在肿瘤发生发展过程中发挥重要作用。已有研究表明，肿瘤来源的miRNA存在于癌症患者的循环核酸中。这一现象提示，检测循环miRNA可能是一种有效的癌症非侵入性诊断方法。在本综述中，我们总结了循环miRNA作为生物标志物在癌症诊断中的应用，以及该领域的最新研究进展。