Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
J Am Chem Soc. 2010 Jan 20;132(2):460-1. doi: 10.1021/ja909571z.
Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acid substrates has been achieved through the use of monoprotected chiral amino acid ligands. The absolute configuration of the resulting olefinated products is consistent with that of a proposed C-H insertion intermediate.
通过使用单保护手性氨基酸配体,实现了 Pd(II)催化的二苯乙酸底物的对映选择性 C-H 烯烃化反应。所得烯烃化产物的绝对构型与所提出的 C-H 插入中间体的构型一致。