钯催化尿苷、脱氧尿苷、尿苷一磷酸及尿苷类似物的C-H烯基化反应。
Palladium-catalyzed C-H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues.
作者信息
Zhao Qin, Xie Ruoqian, Zeng Yuxiao, Li Wanlu, Xiao Guolan, Li Yangyan, Chen Gang
机构信息
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University Shanghai 200240 People's Republic of China
School of Chemistry and Chemical Engineering, Southeast University Nanjing 211189 People's Republic of China.
出版信息
RSC Adv. 2022 Sep 1;12(38):24930-24934. doi: 10.1039/d2ra03681a. eCollection 2022 Aug 30.
The palladium-catalyzed oxidative C-H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported herein. This protocol provides an efficient, atom-economic and environmentally friendly approach to the synthesis of biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.
本文报道了钯催化的尿苷、脱氧尿苷、尿苷一磷酸和尿苷类似物的氧化C-H烯烃化反应。该方法为合成具有生物学重要性的C5-烯烃修饰的含尿嘧啶/尿苷衍生物及药物候选物提供了一种高效、原子经济且环境友好的途径。
Zotero 插件