铑催化1,1 - 二取代烯烃与未官能化醛的高度对映选择性直接分子间氢酰化反应。
Rhodium-catalyzed highly enantioselective direct intermolecular hydroacylation of 1,1-disubstituted alkenes with unfunctionalized aldehydes.
作者信息
Shibata Yu, Tanaka Ken
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
出版信息
J Am Chem Soc. 2009 Sep 9;131(35):12552-3. doi: 10.1021/ja905908z.
PMID:19685873
Abstract
We have established that a cationic rhodium(I)/(R,R)-QuinoxP* complex catalyzes the highly enantioselective direct intermolecular hydroacylation of alpha-substituted acrylamides with unfunctionalized aliphatic aldehydes to yield the corresponding gamma-ketoamides in high yields with excellent ee values.
摘要
我们已经证实，一种阳离子铑（I）/（R，R）-喹喔啉膦*配合物能催化α-取代丙烯酰胺与未官能化脂肪醛的高度对映选择性直接分子间氢甲酰化反应，以高收率和优异的对映体过量值生成相应的γ-酮酰胺。
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