Falvey E, Schibler U
Department of Molecular Biology, University of Geneva, Switzerland.
FASEB J. 1991 Mar 1;5(3):309-14. doi: 10.1096/fasebj.5.3.2001790.
The cell-type-specific expression of many genes is determined at the level of transcription. Transcription factors, acting at promoter and enhancer elements, are involved in the control of this process. To understand the basis of this regulation it has become important to analyze the control of transcription factors themselves. A variety of transcriptional, translational, and posttranslational mechanisms have been described, and are discussed in this review article.
许多基因的细胞类型特异性表达是在转录水平上确定的。作用于启动子和增强子元件的转录因子参与了这一过程的调控。为了理解这种调控的基础，分析转录因子自身的调控变得很重要。本文综述了多种转录、翻译和翻译后机制。
