酒精依赖症发病年龄的新定义。
A new definition of early age at onset in alcohol dependence.
机构信息
INSERM U894/U675, Centre Psychiatrie et Neurosciences, 75014 Paris, France.
出版信息
Drug Alcohol Depend. 2010 Apr 1;108(1-2):43-8. doi: 10.1016/j.drugalcdep.2009.11.011. Epub 2009 Dec 16.
Abstract
OBJECTIVE
The accurate cut-off of an early onset of alcohol dependence is unknown. The objectives of this analysis are (1) to confirm that ages at onset variability in alcohol dependence is best described as a two subgroups entity, (2) to define the most appropriate cut-off, and (3) to test the relevancy of such distinction.
METHOD
Data were drawn the Epidemiologic Survey on Alcohol and Related Conditions (NESARC). This study focused on the 4782 adults with lifetime alcohol dependence.
RESULTS
The best-fit model distinguished two subgroups of age at onset of alcohol dependence, with a cut-off point at 22 years. Subjects with an earlier onset of alcohol dependence (< or = 22 years old) reported higher lifetime rates of specific phobia, antisocial behaviors and nearly all addictive disorders.
CONCLUSIONS
The early onset of alcohol dependence is best defined as beginning before the age of 22 years.
摘要
目的
酒精依赖发病年龄的准确截断值尚不清楚。本分析的目的是：(1) 证实酒精依赖发病年龄的变异性最好用两个亚组实体来描述；(2) 确定最合适的截断值；(3) 检验这种区分的相关性。
方法
数据来自酒精和相关条件的流行病学调查（NESARC）。本研究主要关注 4782 名有终生酒精依赖的成年人。
结果
最佳拟合模型区分了酒精依赖发病年龄的两个亚组，截断值为 22 岁。发病年龄较早的（<=22 岁）患者报告了更高的特定恐惧症、反社会行为和几乎所有成瘾障碍的终生发生率。
结论
酒精依赖的早发性最好定义为发病年龄在 22 岁之前。
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