Graduate Program in Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Hum Exp Toxicol. 2010 Jun;29(6):467-76. doi: 10.1177/0960327109357777. Epub 2009 Dec 17.
Strategies to diminish cadmium (Cd) absorption are highly desirable especially where Cd exposure due to environmental contamination is still inevitable. Cd toxicity may be influenced by dietary components, such as fiber and minerals. Multimixtures are low-cost cereal bran supplements used in Brazil and in other countries to counteract malnutrition in low-income populations. This study was aimed at evaluating whether multimixture would reduce Cd effects in young rats. Animals received a diet with or without the multimixture plus 0, 5, or 25 mg Cd/kg (control, Cd-5, and Cd-25 groups) during 30 days. The Cd-5 groups were similar to control groups in all parameters analyzed, except in the higher renal Cd concentration. However, the Cd-25 groups had lower biological growth parameters and renal delta-aminolevulinate dehydratase activity, besides higher renal Cd concentration and plasma alanine aminotransferase activity compared to the controls. The multimixture did not prevent Cd effects in the Cd-25 group, but caused a small reduction in renal Cd concentration in the Cd-5 group. Although this multimixture was ineffective to prevent Cd effects at the higher concentration, it seemed to reduce Cd accumulation at the lower Cd dietary concentration, which is similar to levels of human exposure in some polluted areas.
减少镉 (Cd) 吸收的策略是非常需要的，特别是在由于环境污染导致 Cd 暴露仍然不可避免的情况下。膳食成分，如纤维和矿物质，可能会影响 Cd 的毒性。多混合物是一种低成本的谷物糠补充剂，在巴西和其他国家用于对抗低收入人群的营养不良。本研究旨在评估多混合物是否会减轻幼鼠的 Cd 效应。动物在 30 天内接受含有或不含有多混合物的饮食，外加 0、5 或 25mgCd/kg（对照组、Cd-5 组和 Cd-25 组）。Cd-5 组在所有分析的参数上与对照组相似，除了肾脏 Cd 浓度较高。然而，与对照组相比，Cd-25 组的生物生长参数和肾脏 δ-氨基-γ-酮戊酸脱水酶活性较低，肾脏 Cd 浓度和血浆丙氨酸氨基转移酶活性较高。多混合物不能预防 Cd-25 组的 Cd 效应，但在 Cd-5 组中，肾脏 Cd 浓度略有降低。尽管这种多混合物在较高浓度下不能预防 Cd 的作用，但它似乎减少了较低 Cd 饮食浓度下的 Cd 积累，这与一些污染地区的人类暴露水平相似。
