Graduate Program on Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Nutr Res. 2010 Sep;30(9):615-25. doi: 10.1016/j.nutres.2010.08.005.
Multimixtures (MMs) are dietary supplements prepared with low-cost ingredients and food by-products that are widely used in various countries to counteract malnutrition. Although MMs have a high content of minerals, they also contain high levels of dietary fiber and associated compounds, which might bind minerals and impair their absorption. In this study, we investigated the hypothesis that the increased dietary fiber content of MMs would impair gastrointestinal mineral absorption due to the metal-binding capacity of dietary fiber. Thus, the objective of the present study was to feed growing rats with a basal diet, representative of a nutritionally deficient diet, alone or supplemented with a low dietary fiber level MM, intermediate dietary fiber level MM, or high dietary fiber level MM (HF) to evaluate the apparent absorption of calcium, phosphorus, magnesium, manganese, and copper. The relative apparent calcium absorption was slightly decreased by the HF addition, with no change in the absolute apparent absorption. The absolute apparent absorption of phosphorus and magnesium was increased by the intermediate dietary fiber level MM and HF additions, whereas the manganese absorption was increased only by the HF addition. The apparent absorption of copper was not affected by the MM supplementation. The increased apparent absorption of minerals was always related to the increase in the mineral dietary concentration triggered by the MM. Thus, we concluded that the increased dietary fiber levels in the MMs increased the mineral levels, and MMs with intermediate and high fiber levels may be used to improve the mineral balance of poor diets.
多混合物（MMs）是用低成本成分和食品副产品制成的膳食补充剂，广泛用于各国以对抗营养不良。虽然 MMs 含有很高的矿物质含量，但它们也含有高水平的膳食纤维和相关化合物，这些化合物可能会与矿物质结合并损害其吸收。在这项研究中，我们假设由于膳食纤维的金属结合能力，MMs 中膳食纤维含量的增加会损害胃肠道矿物质的吸收。因此，本研究的目的是用基础饮食喂养生长大鼠，该基础饮食代表营养不足的饮食，单独或补充低膳食纤维水平的 MM、中膳食纤维水平的 MM 或高膳食纤维水平的 MM（HF），以评估钙、磷、镁、锰和铜的表观吸收率。HF 的添加略微降低了相对表观钙吸收率，而绝对表观吸收率没有变化。中间和高膳食纤维水平的 MM 和 HF 添加增加了磷和镁的绝对表观吸收率，而只有 HF 添加增加了锰的吸收率。MM 补充对铜的表观吸收率没有影响。矿物质的表观吸收率增加始终与 MM 引发的矿物质膳食浓度增加有关。因此，我们得出结论，MMs 中膳食纤维水平的增加增加了矿物质的水平，并且具有中高纤维水平的 MMs 可用于改善贫困饮食的矿物质平衡。
