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GafChromic 薄膜和离子室在低能质子剂量学中的 LET 依赖性。

LET dependence of GafChromic films and an ion chamber in low-energy proton dosimetry.

机构信息

School of Physics and Astronomy, University of Birmingham, Birmingham, B15 2TT, UK.

出版信息

Phys Med Biol. 2010 Jan 21;55(2):417-33. doi: 10.1088/0031-9155/55/2/006. Epub 2009 Dec 17.

Abstract

Dosimetry using a PMMA phantom was performed in 15 and 29 MeV proton beams from the Birmingham cyclotron, with a Markus parallel-plate ionization chamber and GafChromic EBT and MD-V2-55 film. Simulations of the depth-dose curves were performed with FLUKA 2008.3 and MCNPX 2.5.0, which agreed almost perfectly with each other in range and only differed by 2% in the Bragg peak (BP) region. FLUKA was also used to calculate k(Q) factors for Markus chamber measurements as an improvement to the IAEA TRS-398 values in low-energy beams. FLUKA depth-dose simulations overestimate the BP height measured by ion chamber by about 10%, where the initial proton energy spread was estimated by fitting to the slope of the measured BP distal edge. Both GafChromic films showed an under-response in the BP compared to ion chamber; however, EBT exhibits this effect at lower energies than MD-V2-55. A possible reason for this is attributed to the shape and arrangement of the monomer particles being different in the active components of EBT and MD-V2-55. Relative effectiveness (RE) of both films is presented as functions of residual range R(res) in water and peak proton energy determined by FLUKA, with considerations for the spatial separation of the two active layers in each film. The proton energies at which RE reduces to 90% of maximum film response are 6.7 and 3.2 MeV for MD-V2-55 and EBT, respectively. Additionally, a beam quality correction factor (g(Q,Q0)) is suggested for both GafChromic films, involving water-to-film stopping power ratios evaluated using ICRU recommendations, and a polymer yield factor G(Q0)/G(Q). RE in this work is equated to the reciprocal of the polymer yield factor. The calculated values of (S(w,film))Q/(S(w,film))Q0 are constant within 2.1% and 1.2% across the proton energy range of 1-300 MeV for EBT and MD-V2-55, respectively, so it is concluded that the polymer yield factor is the dominant factor causing the LET quenching effect.

摘要

在伯明翰回旋加速器的 15 MeV 和 29 MeV 质子束中,使用 PMMA 体模进行了剂量测定,使用 Markus 平行板电离室和 GafChromic EBT 和 MD-V2-55 胶片。深度剂量曲线的模拟使用了 FLUKA 2008.3 和 MCNPX 2.5.0,这两个程序在射程上几乎完全一致,仅在布喇格峰(BP)区域相差 2%。FLUKA 还用于计算 Markus 室测量的 k(Q)因子,作为对 IAEA TRS-398 在低能束中的值的改进。FLUKA 深度剂量模拟高估了离子室测量的 BP 高度,约高出 10%,其中质子初始能量展宽通过拟合测量的 BP 远侧边缘的斜率来估计。与离子室相比,两种 GafChromic 胶片在 BP 处均表现出响应不足;然而,EBT 在比 MD-V2-55 更低的能量下表现出这种效应。这种情况的一个可能原因归因于 EBT 和 MD-V2-55 的活性成分中单体颗粒的形状和排列不同。两种胶片的相对有效性(RE)呈现为与水的剩余射程 R(res)和由 FLUKA 确定的峰值质子能量的函数,同时考虑到每个胶片中两个活性层的空间分离。RE 降低到胶片最大响应的 90%时的质子能量分别为 MD-V2-55 和 EBT 的 6.7 MeV 和 3.2 MeV。此外,建议对两种 GafChromic 胶片使用束质校正因子(g(Q,Q0),涉及使用 ICRU 建议评估的水到胶片的阻止本领比,以及聚合物产额因子 G(Q0)/G(Q)。在这项工作中,RE 等同于聚合物产额因子的倒数。对于 EBT 和 MD-V2-55,在质子能量范围为 1-300 MeV 时,(S(w,film))Q/(S(w,film))Q0 的计算值在 2.1%和 1.2%以内保持恒定,因此可以得出结论,聚合物产额因子是导致 LET 猝灭效应的主要因素。

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