Department of Genetics and Development, Evolutionary Biology Centre, Uppsala University, SE-75236, Sweden.
Nat Rev Neurosci. 2010 Jan;11(1):9-17. doi: 10.1038/nrn2754.
A plethora of discoveries relating to sex influences on brain function is rapidly moving this field into the spotlight for most areas of neuroscience. The domain of molecular or genetic neuroscience is no exception. The goal of this article is to highlight key developments concerning sex-based dimorphisms in molecular neuroscience, describe control mechanisms regulating these differences, address the implications of these dimorphisms for normal and abnormal brain function and discuss what these advances mean for future work in the field. The overriding conclusion is that, as for neuroscience in general, molecular neuroscience has to take into account potential sex influences that might modify signalling pathways.
大量关于性对大脑功能影响的发现，正在使该领域迅速成为大多数神经科学领域的焦点。分子或遗传神经科学领域也不例外。本文的目的是强调分子神经科学中性别二态性的关键发展，描述调节这些差异的控制机制，探讨这些二态性对正常和异常大脑功能的影响，并讨论这些进展对该领域未来工作的意义。总的结论是，与一般的神经科学一样，分子神经科学必须考虑到可能改变信号通路的潜在性别影响。
