Bux J, Mueller-Eckhardt G, Mueller-Eckhardt C
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, F.R.G.
Hum Immunol. 1991 Jan;30(1):18-21. doi: 10.1016/0198-8859(91)90065-h.
A significant association of autoimmune neutropenia (AIN) in infants due to NA1-specific autoantibodies and HLA-DR2 is reported. Nineteen of 26 infants presenting with AIN and NA1 autoantibodies possessed the DR2 antigen, while only one out of six children with AIN, but non-NA1-specific autoantibodies, was DR2 positive. Furthermore, one adult patient with primary biliary cirrhosis and periods of neutropenia due to NA1 autoantibodies also carried the DR2 antigen. All DR2-negative patients were positive for DRw6. These findings indicate that a close relationship exists between autoimmunization against the NA1 antigen and HLA-DR2 and possibly also DRw6.
据报道，由NA1特异性自身抗体引起的婴儿自身免疫性中性粒细胞减少症（AIN）与HLA - DR2之间存在显著关联。26例出现AIN和NA1自身抗体的婴儿中，有19例具有DR2抗原，而6例患有AIN但非NA1特异性自身抗体的儿童中只有1例DR2呈阳性。此外，一名患有原发性胆汁性肝硬化且因NA1自身抗体出现中性粒细胞减少期的成年患者也携带DR2抗原。所有DR2阴性的患者DRw6均为阳性。这些发现表明，针对NA1抗原的自身免疫与HLA - DR2以及可能的DRw6之间存在密切关系。
