Madyastha P R, Kyong C U, Darby C P, Genco P V, Madyastha K R, Glassman A B, Fudenberg H H
Am J Dis Child. 1982 Aug;136(8):718-21. doi: 10.1001/archpedi.1982.03970440062018.
A nontransfused 14-month-old female infant was investigated for persistent neutropenia of eight months' duration, with absolute neutrophil counts ranging from 410 to 935 cu mm. The patient's sera reacted with neutrophils from her own peripheral blood, from normal donors, and from her mother, all these having the neutrophil antigen NA 1, but not with neutrophils from NA 1-negative donors, including the father. The autoantibody was detectable by capillary agglutination and by indirect immunofluorescence techniques but not by complement-dependent cytotoxicity. No antibody was found in the mother's serum. Studies on three occasions showed good correlation between the appearance of circulating autoantibody and the peripheral neutrophil counts. Our observations, together with previously published reports, suggest a possible relationship of NA 1 antigen and the disease susceptibility of NA 1-positive infants to autoimmune neutropenia.
一名14个月大未接受过输血的女婴因持续8个月的中性粒细胞减少症接受检查，其绝对中性粒细胞计数在410至935立方毫米之间。患者的血清与她自身外周血、正常供体以及她母亲的中性粒细胞发生反应，所有这些中性粒细胞均具有中性粒细胞抗原NA 1，但不与包括父亲在内的NA 1阴性供体的中性粒细胞发生反应。通过毛细管凝集和间接免疫荧光技术可检测到自身抗体，但补体依赖性细胞毒性检测未发现该抗体。母亲血清中未发现抗体。三次研究表明，循环自身抗体的出现与外周中性粒细胞计数之间具有良好的相关性。我们的观察结果与先前发表的报告一起表明，NA 1抗原与NA 1阳性婴儿对自身免疫性中性粒细胞减少症的疾病易感性之间可能存在关联。
