Barnard Chantelle, Goldbach Mort, Whyte Hilary, Ford-Jones Lee, King Susan
Divisions of General Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario.
Paediatr Child Health. 2003 Sep;8(7):439-41. doi: 10.1093/pch/8.7.439.
Although maternal screening and the administration of prophylactic intrapartum antibiotics have decreased the incidence of early onset group B streptococcal (GBS) disease in neonates, there is still significant morbidity and mortality as a result of neonatal GBS disease.Maternal GBS infections are not uncommon, but with appropriate therapy there is almost a uniformly good outcome. Little is written about the appropriate management of well infants born to mothers with postpartum GBS sepsis.The question of whether well infants born to mothers with GBS puerperal sepsis should be treated empirically with antibiotics and the lack of literature concerning this issue became apparent when an untreated term infant died of late onset GBS meningitis following maternal puerperal GBS sepsis. We describe this event in the following case presentation.With the current paucity of literature regarding the management of well infants born to mothers with postpartum GBS sepsis, it seems prudent to treat such infants empirically with antibiotics (following a full septic work-up) until this matter has been investigated further.
尽管孕产妇筛查和预防性产时抗生素的使用已降低了新生儿早发型B族链球菌（GBS）疾病的发病率，但新生儿GBS疾病仍会导致显著的发病和死亡。孕产妇GBS感染并不罕见，但通过适当治疗，几乎总能取得良好的治疗效果。关于产后GBS败血症母亲所生健康婴儿的适当管理，相关文献较少。当一名未经治疗的足月儿在母亲产后GBS败血症后死于晚发型GBS脑膜炎时，对于GBS产褥期败血症母亲所生健康婴儿是否应经验性使用抗生素治疗以及缺乏关于此问题的文献这一情况就变得很明显了。我们在以下病例报告中描述这一事件。鉴于目前关于产后GBS败血症母亲所生健康婴儿管理的文献匮乏，在对此问题进行进一步研究之前，对这类婴儿进行全面的败血症检查后经验性使用抗生素治疗似乎是谨慎之举。
