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膀胱癌的化学预防:有哪些新进展?

Chemoprevention in bladder cancer: What's new?

作者信息

Lattouf Jean-Baptiste

机构信息

Department of Surgery, Urologic Oncology Section and Minimally Invasive Section, University of Montréal Health Centre (CHUM), Montréal, QC.

出版信息

Can Urol Assoc J. 2009 Dec;3(6 Suppl 4):S184-7. doi: 10.5489/cuaj.1193.

DOI:10.5489/cuaj.1193
PMID:20019982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2792454/
Abstract

Bladder cancer is the sixth most common tumour in Canada and ranks eighth in terms of cancer mortality. Up to now, management of this condition relied mostly on surgical and intravesical treatments once the disease is established. Chemoprevention is an attractive option to prevent the disease in high-risk populations and may well reduce the costs related to its treatment. This review examines the available data on chemoprevention strategies in bladder cancer, with special emphasis on randomized controlled trials when available.

摘要

膀胱癌是加拿大第六大常见肿瘤,在癌症死亡率方面排名第八。到目前为止,一旦疾病确诊,这种疾病的治疗主要依靠手术和膀胱内治疗。化学预防是预防高危人群患膀胱癌的一种有吸引力的选择,并且很可能降低其治疗相关成本。本综述研究了膀胱癌化学预防策略的现有数据,特别强调了现有随机对照试验。

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引用本文的文献

1
Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach.用于膀胱癌化学预防的萝卜硫素:靶向分子机制方法
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2
Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer.ω-3 脂肪酸抑制膀胱癌大鼠模型中的肿瘤生长。
Biomed Res Int. 2013;2013:368178. doi: 10.1155/2013/368178. Epub 2013 Jun 20.
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Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells.氧化应激在葡萄籽提取物对人膀胱癌细胞细胞毒性中的作用。
Food Chem Toxicol. 2013 Nov;61:187-95. doi: 10.1016/j.fct.2013.06.039. Epub 2013 Jul 3.
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Tea consumption and risk of bladder cancer: a meta-analysis.饮茶与膀胱癌风险:一项荟萃分析。
World J Surg Oncol. 2012 Aug 25;10:172. doi: 10.1186/1477-7819-10-172.

本文引用的文献

1
Randomized prospective phase III trial of difluoromethylornithine vs placebo in preventing recurrence of completely resected low risk superficial bladder cancer.二氟甲基鸟氨酸与安慰剂预防完全切除的低风险浅表性膀胱癌复发的随机前瞻性III期试验。
J Urol. 2006 Aug;176(2):500-4. doi: 10.1016/j.juro.2006.03.061.
2
Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24.抗坏血酸、赖氨酸、脯氨酸、精氨酸和绿茶提取物对膀胱癌细胞系T-24的抗肿瘤作用。
Int J Urol. 2006 Apr;13(4):415-9. doi: 10.1111/j.1442-2042.2006.01309.x.
3
Bladder cancer clinical trials.膀胱癌临床试验。
Urol Oncol. 2005 Jul-Aug;23(4):275-9. doi: 10.1016/j.urolonc.2005.05.005.
4
Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality.荟萃分析:补充高剂量维生素E可能会增加全因死亡率。
Ann Intern Med. 2005 Jan 4;142(1):37-46. doi: 10.7326/0003-4819-142-1-200501040-00110. Epub 2004 Nov 10.
5
Carotenoids/vitamin C and smoking-related bladder cancer.类胡萝卜素/维生素C与吸烟相关的膀胱癌
Int J Cancer. 2004 Jun 20;110(3):417-23. doi: 10.1002/ijc.20104.
6
Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate.绿茶衍生物表没食子儿茶素-3-没食子酸酯对膀胱肿瘤生长的抑制作用。
J Urol. 2003 Sep;170(3):773-6. doi: 10.1097/01.ju.0000081278.64511.96.
7
Dietary soy and increased risk of bladder cancer: the Singapore Chinese Health Study.膳食中的大豆与膀胱癌风险增加:新加坡华人健康研究
Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1674-7.
8
Vitamin C and vitamin E supplement use and bladder cancer mortality in a large cohort of US men and women.美国大量男性和女性队列中维生素C和维生素E补充剂的使用与膀胱癌死亡率
Am J Epidemiol. 2002 Dec 1;156(11):1002-10. doi: 10.1093/aje/kwf147.
9
Fluid consumption and the risk of bladder cancer: results of a multicenter case-control study.
Int J Cancer. 2001 Sep;93(6):880-7. doi: 10.1002/ijc.1411.
10
Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries.非吸烟者的咖啡摄入量与膀胱癌:欧洲国家病例对照研究的汇总分析
Cancer Causes Control. 2000 Dec;11(10):925-31. doi: 10.1023/a:1026524014954.