利用多种高亲和力同种反应性 T 细胞对 Tap 缺陷性淋巴瘤进行有效的过继性治疗。
Effective adoptive therapy of tap-deficient lymphoma using diverse high avidity alloreactive T cells.
机构信息
Michael Heidelberger Division of Immunology, Department of Pathology and NYU Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
出版信息
Cancer Immunol Immunother. 2010 Apr;59(4):629-33. doi: 10.1007/s00262-009-0805-5. Epub 2009 Dec 18.
Abstract
High avidity for antigen and diversity of T cell receptor (TCR) repertoire are essential for effective immunity against cancer. We have previously created a transgenic mouse strain with increased TCR avidity in a diverse T cell population. In this report, we show that strong alloreactive responses of transgenic T cells against targets with low MHC class I expression can be used for effective adoptive transfer of tumor immunity in vivo. Alloreactive transgenic T cells could be an effective therapeutic approach counteracting tumor evasion of the immune system.
摘要
高抗原亲和力和 T 细胞受体 (TCR) 库的多样性对于有效对抗癌症的免疫至关重要。我们之前创建了一种转基因小鼠品系，该品系中多样化的 T 细胞群体的 TCR 亲和力增加。在本报告中，我们表明，针对 MHC Ⅰ类表达低的靶标，转基因 T 细胞的强烈同种反应性应答可用于体内有效过继转移肿瘤免疫。同种反应性转基因 T 细胞可能是一种有效的治疗方法，可以对抗肿瘤逃避免疫系统。
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