Maslennikova A V, Balalaeva I V, Gladkova N D, Karabut M M, Kiseleva E B, Iksanov R R, Il'in N I, Sokurenko V P
Vopr Onkol. 2009;55(5):572-9.
The results of oral mucosa monitoring by optical coherence tomography (OCT) in the course of radiochemotherapy of 18 cases of oropharyngeal cancer are discussed. Damage to the mucosa was mainly assessed using contrast characteristics deterioration and reduction of epithelial layer thickness. Significant variation in OCT image characteristics was identified vs. mucositis grade and prognostic criteria for individual mucosal radiosensitivity worked out intact contrast on day 1 of mucositis should be interpreted as a sign of relatively mild complication. Blurred contrast would indicate mucositis stage III-IV development. Numerical analysis of OCT image patterns confirmed the contribution of the endothelial blood vessels and connecting tissue to radiation-induced damage to the mucosa.
讨论了18例口咽癌患者在放化疗过程中通过光学相干断层扫描（OCT）进行口腔黏膜监测的结果。主要通过对比特征的恶化和上皮层厚度的减少来评估黏膜损伤情况。与黏膜炎分级相比，OCT图像特征存在显著差异，并制定了个体黏膜放射敏感性的预后标准。黏膜炎第1天完整的对比应被解释为相对轻度并发症的迹象。对比模糊表明黏膜炎处于III-IV期发展。OCT图像模式的数值分析证实了内皮血管和结缔组织对辐射诱导的黏膜损伤的作用。
