López-Castaño Fuensanta, Oñate-Sánchez Ricardo E, Roldán-Chicano Rocío, Cabrerizo-Merino Maria Carmen
Unidad Docente Pacientes Especiales, Clínica Odontológica Universitaria Murcia.
Med Oral Patol Oral Cir Bucal. 2005 Nov-Dec;10(5):412-21.
Oral mucositis is the inflammation that takes place in the oral epithelium, as a result of antineoplastic treatments such as radiotherapy, chemotherapy or bone marrow transplant, being very frequent in these treatments for oncohematologic disease. The consequences of this inflammation, not only affect the quality of life of the patient, but can also suppose a limitation in the application of the treatment, as well as an increase in the hospital stay and therapeutic costs. A main obstacle for the study of the mucositis, has been the lack of a system adapted for its valuation by means of the oral examination. Methods developed to measure and quantify the changes produced in oral epithelium as a result of treatment of cancer can be very varied from more simple methods, such as general scales with four or five degrees of severity that link the mucositis to the state of oral health, to specific scales of treatment. In this last type of scale the type of antineoplastic treatment that gave rise to the mucositis is identified giving a global severity score for the mucositis. The establishment of a common scale for the evaluation of mucositis is important, not only for clinical purposes but also for the investigation of the degree of toxicity of the different therapeutic regimes that give rise to the mucositis.
口腔黏膜炎是口腔上皮发生的炎症，是由放疗、化疗或骨髓移植等抗肿瘤治疗引起的，在这些血液肿瘤疾病的治疗中非常常见。这种炎症的后果不仅会影响患者的生活质量，还可能导致治疗应用受限、住院时间延长和治疗费用增加。口腔黏膜炎研究的一个主要障碍是缺乏一种适用于通过口腔检查进行评估的系统。为测量和量化癌症治疗导致口腔上皮产生的变化而开发的方法多种多样，从更简单的方法，如将黏膜炎与口腔健康状况联系起来的四度或五度严重程度的一般量表，到特定的治疗量表。在最后一种量表中，确定引起黏膜炎的抗肿瘤治疗类型，并给出黏膜炎的总体严重程度评分。建立一个评估黏膜炎的通用量表很重要，这不仅出于临床目的，也有助于研究导致黏膜炎的不同治疗方案的毒性程度。
