Stefano G B, Smith E M, Hughes T K
Multidisciplinary Center for the Study of Aging, State University of New York, College Old Westbury 11568.
J Neuroimmunol. 1991 Apr;32(1):29-34. doi: 10.1016/0165-5728(91)90068-i.
The synthetic analog of methionine enkephalin, [D-Ala2-Met5]-enkephalin, when administered in vitro to Mytilus edulis ganglia and hemocytes and human peripheral blood lymphocytes, induces the formation of an immunoreactive interleukin-1-like molecule. Additionally, immunoreactive interleukin-1 (IL-1) activity has been found in Mytilus nervous tissue. The stimulatory actions of the extracted immunoreactive IL-1 on Mytilus hemocytes can be antagonized by an IL-1 antibody demonstrating the specificity of the substance. The evidence suggests that the nervous system, via an opioid-IL-1 relationship, can communicate with the immune/defense system through these similar signal molecules. Furthermore, the results indicate that an interleukin-like molecule must have evolved earlier than previously thought.
甲硫氨酸脑啡肽的合成类似物[D - Ala2 - Met5] - 脑啡肽，在体外给予紫贻贝神经节、血细胞以及人外周血淋巴细胞时，会诱导形成一种具有免疫反应性的白细胞介素 - 1样分子。此外，在紫贻贝神经组织中也发现了具有免疫反应性的白细胞介素 - 1（IL - 1）活性。提取的具有免疫反应性的IL - 1对紫贻贝血细胞的刺激作用可被IL - 1抗体拮抗，这证明了该物质的特异性。证据表明，神经系统可通过阿片样物质 - IL - 1关系，借助这些相似的信号分子与免疫/防御系统进行沟通。此外，结果表明一种白细胞介素样分子的进化时间肯定比之前认为的要早。
