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Isolation and characterization of a primitive interleukin-1-like protein from an invertebrate, Asterias forbesi.从无脊椎动物福布斯海盘车（Asterias forbesi）中分离并鉴定一种原始的白细胞介素-1样蛋白。
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白细胞介素-1对苹果螺（Helix pomatia L.）特定神经元上电压激活离子电流的调节作用。

Modulation of voltage-activated ion currents on identified neurons of Helix pomatia L. by interleukin-1.

作者信息

Szûcs A, Stefano G B, Hughes T K, Rózsa K S

机构信息

Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany.

出版信息

Cell Mol Neurobiol. 1992 Oct;12(5):429-38. doi: 10.1007/BF00711543.

DOI:10.1007/BF00711543
PMID:1281756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11567299/
Abstract
  1. The effect of interleukin-1 (IL-1) was studied on voltage-activated ion currents of the identified central neurons of Helix pomatia L. using a two-microelectrode voltage clamp. The voltage-activated inward current (ICa) was decreased, whereas the outward current (I(net) K) was increased by IL-1. 2. IL-1 affects both the transient and the delayed rectifying potassium currents. The IL-1 modulatory effect on the voltage-activated ion currents was voltage and dose dependent. The threshold concentration for IL-1 was 2 U/ml. 3. The proposed modulatory effect of IL-1 appears to have more than one site of action on the neuron membrane ion channels. 4. Rabbit anti-human IL-1 polyclonal antiserum eliminated the IL-1 effects on the voltage-activated inward and outward currents. This is the first report demonstrating a direct effect of IL-1 modulation of voltage-activated ion currents on neurons of mollusks.
摘要
  1. 使用双微电极电压钳研究了白细胞介素-1（IL-1）对苹果螺（Helix pomatia L.）已鉴定的中枢神经元电压激活离子电流的影响。IL-1使电压激活内向电流（ICa）降低，而外向电流（I(net) K）增加。2. IL-1影响瞬时钾电流和延迟整流钾电流。IL-1对电压激活离子电流的调节作用具有电压和剂量依赖性。IL-1的阈值浓度为2 U/ml。3. 所提出的IL-1调节作用似乎在神经元膜离子通道上有多个作用位点。4. 兔抗人IL-1多克隆抗血清消除了IL-1对电压激活内向和外向电流的影响。这是首次报道IL-1对软体动物神经元电压激活离子电流的调节作用。