Sharief M K, Hentges R, Thompson E J
Department of Clinical Neurochemistry, National Hospital for Neurology and Neurosurgery, London, U.K.
J Neuroimmunol. 1991 Apr;32(1):43-51. doi: 10.1016/0165-5728(91)90070-n.
The in vivo relationship of interleukin-2 (IL-2) to the local humoral immune response within the central nervous system (CNS) in patients with multiple sclerosis (MS) is hitherto largely unknown. Intrathecal levels of IL-2 and soluble IL-2 receptors (sIL-2R) were correlated to the local CNS synthesis of immunoglobulin G, A, D, and M isotypes in 70 patients with clinically definite MS. Levels were also determined in 19 normal control subjects to establish normal reference limits. High cerebrospinal fluid levels of IL-2 and sIL-2R were detected mainly in patients with acute relapsing-remitting MS and were significantly higher than corresponding serum levels. Intrathecal levels of IL-2 significantly correlated with local CNS synthesis of IgD and IgM, while no correlation was found with either IgG or IgA. Similarly, intrathecal sIL-2R levels significantly correlated with local CNS production of IgD and IgM, but not IgG or IgA. These findings further extend previous reports and also suggest that IL-2 and sIL-2R are involved in the early intrathecal humoral immune response in MS.
多发性硬化症（MS）患者体内白细胞介素-2（IL-2）与中枢神经系统（CNS）局部体液免疫反应之间的关系迄今仍 largely unknown。在70例临床确诊的MS患者中，鞘内IL-2和可溶性IL-2受体（sIL-2R）水平与CNS局部免疫球蛋白G、A、D和M亚型的合成相关。还测定了19名正常对照受试者的水平以建立正常参考范围。IL-2和sIL-2R的高脑脊液水平主要在急性复发缓解型MS患者中检测到，且显著高于相应的血清水平。鞘内IL-2水平与CNS局部IgD和IgM的合成显著相关，而与IgG或IgA均无相关性。同样，鞘内sIL-2R水平与CNS局部IgD和IgM的产生显著相关，但与IgG或IgA无关。这些发现进一步扩展了先前的报道，也表明IL-2和sIL-2R参与了MS早期的鞘内体液免疫反应。
