Ciardi M, Sharief M K, Noori M A, Thompson E J, Salotti A, Rossi F, Vullo V, Catania S, Sorice F, Cirelli A
Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, U.K.
J Neurol Sci. 1993 Mar;115(1):117-22. doi: 10.1016/0022-510x(93)90076-b.
The relationship between the interleukin-2 (IL-2) system and the humoral response against human immunodeficiency virus type-I (HIV-1) is important in understanding the immune reaction before the development of AIDS. Levels of IL-2 and soluble IL-2 receptor (sIL-2R) in serum and cerebrospinal fluid (CSF) samples from 31 asymptomatic HIV-1 seropositive individuals were measured and correlated with levels of anti-1 IgG and IgM antibodies. High IL-2 levels were detected in the CSF of 20 (65%) subjects, 18 (90%) of whom had evidence of intrathecal synthesis of HIV-1-specific IgM antibodies. Similarly, IgG antibodies were detected in 10 subjects who had elevated IL-2 levels in the CSF. Moreover, intrathecal levels of IL-2 and sIL-2R correlated with intrathecal synthesis of both IgG and IgM antibodies. Local release of IL-2 seems to play an important role in the initiation of the antibody response against HIV-1 in early stages of infection and may be utilised in devising effective therapeutic strategies.
白细胞介素-2（IL-2）系统与针对I型人类免疫缺陷病毒（HIV-1）的体液反应之间的关系，对于理解艾滋病发展之前的免疫反应非常重要。对31名无症状HIV-1血清阳性个体的血清和脑脊液（CSF）样本中的IL-2和可溶性IL-2受体（sIL-2R）水平进行了测量，并将其与抗HIV-1 IgG和IgM抗体水平相关联。在20名（65%）受试者的脑脊液中检测到高IL-2水平，其中18名（90%）有鞘内合成HIV-1特异性IgM抗体的证据。同样，在10名脑脊液中IL-2水平升高的受试者中检测到IgG抗体。此外，IL-2和sIL-2R的鞘内水平与IgG和IgM抗体的鞘内合成相关。IL-2的局部释放似乎在感染早期针对HIV-1的抗体反应启动中起重要作用，并且可能用于设计有效的治疗策略。
