与多发性硬化症相关的HLA-DQβ等位基因的寡核苷酸斑点杂交分析。
Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis.
作者信息
Sinha A A, Bell R B, Steinman L, McDevitt H O
机构信息
Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.
出版信息
J Neuroimmunol. 1991 Apr;32(1):61-5. doi: 10.1016/0165-5728(91)90072-f.
PMID:2002091
Abstract
Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.
摘要
使用寡核苷酸探针来研究DQβ分子在多发性硬化易感性中的作用。尽管有人提出DQβ1中共享的氨基酸和核苷酸序列在疾病发展中至关重要，但我们发现，与71-77位残基相对应的序列在患者中的分布并不比对照组中更高。
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