Saeki H, Kuwata S, Nakagawa H, Etoh T, Yanagisawa M, Miyamoto M, Tokunaga K, Juji T, Shibata Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Allergy Clin Immunol. 1995 Dec;96(6 Pt 2):1061-8. doi: 10.1016/s0091-6749(95)70191-5.
We investigated the association between HLA class II alleles and severe atopic dermatitis with high serum IgE levels (greater than 8000 U/ml). The frequencies of HLA-DRB11302 and DQB10604 were increased, whereas the frequency of HLA-DQB10302 was decreased. A strong haplotype, HLA-DRB11302-DQB10604, has been reported in the Japanese population, and this haplotype is conserved in patients with AD. Further analysis of the amino acid epitopes on the HLA-DR beta 1 and DQ beta 1 domains revealed that DR beta 1 71Glu (RR = 5.71, p < 0.05) and DQ beta 1 30His (RR = 3.25 p < 0.01), and 57Val (RR = 3.13, p < 0.05) were increased in frequency. DR beta 1 71Glu was exclusively unique to DRB11302. DQ beta 1 30His was shared by the following alleles: DQ beta 1*0501, *0502, 0503, and 0604, which were all increased in patients with AD. DQ beta 1 57Val was shared by DQB10501 and 0604. A well-known haplotype, HLA-DRB11302-DQB10604, contains DR beta 1 71Glu and DQ beta 1 30His and 57Val. Therefore HLA-DR beta 1 71Glu and/or DQ beta 1 30His/57Val are considered to play the most important role in the development of atopic dermatitis.
