Voriconazole therapeutic drug monitoring: focus on safety.

IMPORTANCE OF THE FIELD

Voriconazole has been widely used for the treatment of invasive fungal diseases, particularly invasive aspergillosis. Drug-drug interactions are, however, the main drawback associated with voriconazole use, since this drug suffers from extensive hepatic metabolism.

AREAS COVERED IN THIS REVIEW

This article reviews the current literature on voriconazole therapeutic drug monitoring, with a special focus on drug safety.

WHAT THE READER WILL GAIN

An update on voriconazole metabolism, drug interactions, toxicity and the relation of these with voriconazole drug concentrations.

TAKE HOME MESSAGE

Therapy with voriconazole may be better guided by measuring voriconazole concentrations in the plasma.