Universidade Federal do Rio Grande do Sul, Post Graduation Program in Pulmonary Sciences, Porto Alegre, Brazil.
Expert Opin Drug Saf. 2010 Jan;9(1):125-37. doi: 10.1517/14740330903485637.
Voriconazole has been widely used for the treatment of invasive fungal diseases, particularly invasive aspergillosis. Drug-drug interactions are, however, the main drawback associated with voriconazole use, since this drug suffers from extensive hepatic metabolism.
This article reviews the current literature on voriconazole therapeutic drug monitoring, with a special focus on drug safety.
An update on voriconazole metabolism, drug interactions, toxicity and the relation of these with voriconazole drug concentrations.
Therapy with voriconazole may be better guided by measuring voriconazole concentrations in the plasma.
伏立康唑已被广泛用于治疗侵袭性真菌感染，特别是侵袭性曲霉菌病。然而，药物-药物相互作用是与伏立康唑使用相关的主要缺点，因为这种药物经历广泛的肝脏代谢。
本文综述了目前关于伏立康唑治疗药物监测的文献，特别关注药物安全性。
更新伏立康唑代谢、药物相互作用、毒性及其与伏立康唑药物浓度的关系。
通过测量血浆中的伏立康唑浓度，伏立康唑的治疗可能得到更好的指导。
Zotero 插件