TLRs (Toll-like receptors), NLRs (Nod-like proteins) and RLRs (RIG-like receptors), pathogens sensors of innate immunity conference organized by EuroSciCon hosted a large group of scientists from across Europe. The Chairs hoped the meeting would "provide an overview of these three families of receptors and provide the most recent advances in the area of innate immune pattern recognition", with a view to informing future directions in this field. Eleven talks and six posters were presented; the Chairs gave a detailed introduction, followed by a detailed summation at the end. This article aims to describe the key topics highlighted.