Department of Immunology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands.
Expert Rev Neurother. 2010 Jan;10(1):59-76. doi: 10.1586/ern.09.144.
This review describes patients with schizophrenia and bipolar disorder. In such patients, a high inflammatory set point of circulating monocytes at the transcriptome level is observed, involving various inflammatory transcripts forming distinct fingerprints (the transcriptomic monocyte fingerprint in schizophrenia overlaps with that in bipolar disorder, but also differs with it at points). There are increased levels of compounds of the IL-1, IL-6 and TNF system in the serum (be it modest and inconsistent). There is also evidence that the IL-2 system is activated in patients with schizophrenia (and perhaps those with mania), although independently of the activation of the IL-1, IL-6 and TNF systems, suggesting separate inducing mechanisms for monocyte and T-cell activation. It is not yet known whether such T cell activation involves the Th1/Th2/Th17 or Treg systems.
这篇综述描述了精神分裂症和双相情感障碍患者的情况。在这些患者中，循环单核细胞的转录组水平上存在高炎症起始点，涉及到各种形成不同特征指纹的炎症转录本（精神分裂症的转录组单核细胞指纹与双相情感障碍重叠，但也存在差异）。血清中白细胞介素-1 (IL-1)、白细胞介素-6 (IL-6) 和肿瘤坏死因子 (TNF) 系统的化合物水平升高（程度轻微且不一致）。也有证据表明，精神分裂症患者（可能还有躁狂症患者）的白细胞介素-2 系统被激活，尽管与白细胞介素-1、白细胞介素-6 和 TNF 系统的激活无关，提示单核细胞和 T 细胞激活存在独立的诱导机制。目前尚不清楚这种 T 细胞激活是否涉及 Th1/Th2/Th17 或 Treg 系统。
