Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA, USA.
Curr Mol Pharmacol. 2009 Jan;2(1):134-9. doi: 10.2174/1874467210902010134.
The therapeutic potential of cannabinoids has been studied and investigated through centuries, although many interesting discoveries have emerged from this field in the past decades. Indeed, peripheral analgesic effects of cannabinoids are a new avenue of treatment since they are avoiding the deleterious central side effects of systemic administration. Recently, it has been demonstrated that cannabinoid receptors (more specifically CB(1) and CB(2) receptors) and their endogenous ligands are present at the peripheral level, especially in different layers of skin, and mostly, in the epidermis and dermis. Those findings are reinforcing and confirming the efficacy of peripheral administration of cannabinoids used to alleviate pain in many different animal models. However, many studies have shown that the endocannabinoid system interacts with other receptors and pathways to modulate pain at the peripheral level. Thereof, the main goal of this review is to explain, in a better way, the different interactions regarding the cannabinoid system with other cellular components of its environment, its involvement in the modulation of pain at the peripheral level and, more precisely, in different layers of the skin.
几个世纪以来，人们一直在研究和探索大麻素的治疗潜力，尽管过去几十年来该领域有许多有趣的发现。事实上，大麻素的外周镇痛作用是一种新的治疗途径，因为它们避免了全身给药的有害中枢副作用。最近，已经证明大麻素受体（更具体地说是 CB(1)和 CB(2)受体）及其内源性配体存在于外周水平，特别是在皮肤的不同层，主要是在表皮和真皮中。这些发现加强并证实了在外周给予大麻素缓解疼痛的有效性，这种方法已在许多不同的动物模型中得到验证。然而，许多研究表明，内源性大麻素系统与其他受体和途径相互作用，以在外周水平调节疼痛。因此，本综述的主要目的是更好地解释大麻素系统与其他细胞成分及其环境的不同相互作用，其在调节外周疼痛中的作用，更确切地说，是在皮肤的不同层中的作用。
