Wang Wen-bin, Li Yue-hong, Liu Bing, Wang Heng-shu, Cui Ai-rong, Zhnag Xiang-hong
Department of Hepatobiliary Surgery, Second Hospital of Hebei Medical Universary, Shijiazhuang 050000, China.
Zhonghua Zhong Liu Za Zhi. 2009 Oct;31(10):773-7.
To evaluate the expression of vascular endothelial growth factor C (VEGF-C) and peroxisome proliferators-activated receptors (PPARgamma) in extrahepatic cholangioadenocarcinoma (EHCAC) and to elucidate its correlation with clinicopathological factors and their significance in prognosis.
The expressions of PPARgamma and VEGF-C were detected by immunohistochemistry in 69 cases of EHCAC, 12 cases of non-tumor bile duct epithelium, and their relationship to clinicopathological parameters and follow-up were analyzed.
The positive rate of PPARgamma expression in 69 cases of EHCAC was 59.4%, significantly higher than that in 12 cases of non-tumor bile duct epithelium (0%), (P < 0.01). The positive rate of VEGF-C in 69 cases of EHCAC was 84.1%, also significantly higher than 16.7% in 12 cases of benign bile duct epithelium (P < 0.05). PPARgamma expression was associated with clinical TNM stage and lymph node metastasis. VEGF-C expression was associated with lymph node metastasis. Cox analysis results showed that portal vein and/or hepatic artery invasion, lymph node metastasis and VEGF-C expression were independent prognostic factors of EHCAC (P < 0.05).
PPARgamma expression may play an important role during tumorigenesis of extrahepatic cholangioadenocarcinoma. The expressions of PPARgamma and VEGF-C are significantly correlated with the clinicopathological characteristics and biological behavior of EHCAC. Expression of VEGF-C is an independent prognosis factors in EHCAC. The detection of PPARgamma and VEGF-C is valuable for evaluation of prognosis of EHCAC.
评估血管内皮生长因子C（VEGF-C）和过氧化物酶体增殖物激活受体（PPARγ）在肝外胆管腺癌（EHCAC）中的表达，阐明其与临床病理因素的相关性及其对预后的意义。
采用免疫组织化学法检测69例EHCAC、12例非肿瘤性胆管上皮中PPARγ和VEGF-C的表达，并分析其与临床病理参数及随访情况的关系。
69例EHCAC中PPARγ表达阳性率为59.4%，显著高于12例非肿瘤性胆管上皮中的阳性率（0%），（P<0.01）。69例EHCAC中VEGF-C阳性率为84.1%，也显著高于12例良性胆管上皮中的16.7%（P<0.05）。PPARγ表达与临床TNM分期及淋巴结转移有关。VEGF-C表达与淋巴结转移有关。Cox分析结果显示门静脉和/或肝动脉侵犯、淋巴结转移及VEGF-C表达是EHCAC的独立预后因素（P<0.05）。
PPARγ表达可能在肝外胆管腺癌的肿瘤发生过程中起重要作用。PPARγ和VEGF-C的表达与EHCAC的临床病理特征及生物学行为显著相关。VEGF-C表达是EHCAC的独立预后因素。检测PPARγ和VEGF-C对评估EHCAC的预后具有重要价值。
