Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, People's Republic of China.
Ann Surg Oncol. 2011 Mar;18(3):872-9. doi: 10.1245/s10434-010-1303-x. Epub 2010 Sep 17.
Overexpressions of hepatoma-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) play important roles in the development and progression of cancers. This study investigates the expression of HDGF combined with VEGF, their correlation with clinicopathologic features, and their prognosis in human hilar cholangiocarcinoma.
The expressions of HDGF and VEGF were analyzed by immunohistochemistry using the streptavidin peroxidase complex method for 58 patients with hilar cholangiocarcinoma receiving surgery. Their correlation with clinicopathologic features was then investigated. The relationships between them and the survival time of patients were retrospectively analyzed.
HDGF and VEGF were positively expressed in 27 (46.6%) and 42 (72.4%) patients, respectively. HDGF and VEGF had a positive correlation (r = 0.370, P = 0.004) in the Spearman rank correlation analysis. HDGF expression was associated with gender and histological type. Patients with positive HDGF expression had a significantly poorer overall survival rate than those with negative HDGF expression (35.7 vs. 73.3%, P = 0.003). Multivariate analysis showed that HDGF expression is an independent prognostic factor.
HDGF expression significantly correlates with VEGF expression and is a valuable prognostic factor for human hilar cholangiocarcinoma.
肝癌衍生生长因子（HDGF）和血管内皮生长因子（VEGF）的过表达在癌症的发展和进展中起着重要作用。本研究探讨了 HDGF 与 VEGF 的表达，及其与人类肝门部胆管癌临床病理特征的相关性，并分析其对预后的影响。
采用免疫组织化学链霉亲和素过氧化物酶复合物法检测 58 例接受手术治疗的肝门部胆管癌患者的 HDGF 和 VEGF 表达，分析其与临床病理特征的关系，并对其与患者生存时间的关系进行回顾性分析。
HDGF 和 VEGF 的阳性表达率分别为 46.6%（27/58）和 72.4%（42/58）。Spearman 秩相关分析显示，HDGF 和 VEGF 表达呈正相关（r=0.370，P=0.004）。HDGF 表达与性别和组织学类型有关。HDGF 阳性表达患者的总生存率明显低于 HDGF 阴性表达患者（35.7%比 73.3%，P=0.003）。多因素分析显示，HDGF 表达是独立的预后因素。
HDGF 表达与 VEGF 表达显著相关，是人类肝门部胆管癌有价值的预后因素。
