Gilmore R L, Falace P, Kanga J, Baumann R
Department of Neurology, College of Medicine, University of Kentucky, Lexington 40536-0084.
J Child Neurol. 1991 Jan;6(1):73-7. doi: 10.1177/088307389100600115.
Möbius syndrome is a complex neurologic disorder characterized by congenital bilateral facial paralysis associated with lateral gaze paralysis. The syndrome has variable manifestations and several variants, some with somatic stigmata. In 1990, Möbius syndrome is conceptualized as a spectrum of clinical caudal brain-stem signs. Some deficits are manifested by laryngeal paralysis and aspiration. Sleep-disordered breathing syndromes have not been previously reported in association with Möbius syndrome. We report two children with Möbius syndrome and sleep-disordered breathing. Based on known pathologic findings and clinical manifestations, we believe that sleep-disordered breathing may be a common complication of Möbius syndrome and should be sought, since potential outcomes of such complications include serious morbidity.
莫比乌斯综合征是一种复杂的神经系统疾病，其特征为先天性双侧面瘫并伴有外展神经麻痹。该综合征有多种表现形式和几种变异型，有些伴有躯体特征。1990年，莫比乌斯综合征被概念化为一系列临床尾侧脑干体征。一些缺陷表现为喉麻痹和误吸。此前尚未有睡眠呼吸障碍综合征与莫比乌斯综合征相关的报道。我们报告了两名患有莫比乌斯综合征和睡眠呼吸障碍的儿童。基于已知的病理发现和临床表现，我们认为睡眠呼吸障碍可能是莫比乌斯综合征的常见并发症，应该进行筛查，因为此类并发症的潜在后果包括严重发病。
