毛囊真皮细胞综述。
Review of hair follicle dermal cells.
机构信息
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
J Dermatol Sci. 2010 Jan;57(1):2-11. doi: 10.1016/j.jdermsci.2009.11.005.
Abstract
Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells. The dermal compartment of the hair follicle consists of the dermal papilla and dermal sheath. Interactions between hair follicle epithelial and dermal cells are necessary for hair follicle morphogenesis during development and in hair reconstitution assays. Dermal papilla and dermal sheath cells express specific markers and possess distinctive morphology and behavior in culture. These cells can induce hair follicle differentiation in epithelial cells and are required in hair reconstitution assays either in the form of intact tissue, dissociated freshly prepared cells or cultured cells. This review will focus on hair follicle dermal cells since most therapeutic efforts to date have concentrated on this aspect of the hair follicle, with the idea that enriching hair-inductive dermal cell populations and expanding their number by culture while maintaining their properties, will establish an efficient hair reconstitution assay that could eventually have therapeutic implications.
摘要
毛囊干细胞位于上皮隆起处，是毛发生长期中毛囊持续再生的根源。隆起处的细胞位于真皮细胞组成的龛位中。毛囊的真皮部分包括毛囊乳头和毛囊鞘。在发育过程中和毛发重建实验中，毛囊上皮细胞与真皮细胞之间的相互作用对于毛囊形态发生是必需的。真皮乳头和毛囊鞘细胞表达特定的标记物，并在培养中具有独特的形态和行为。这些细胞可以诱导上皮细胞的毛囊分化，并且在毛发重建实验中无论是完整组织、新鲜分离的细胞还是培养细胞的形式都必不可少。本综述将重点关注毛囊真皮细胞，因为迄今为止大多数治疗方法都集中在毛囊的这一方面，其理念是通过培养丰富具有毛发诱导能力的真皮细胞群体并扩大其数量，同时保持其特性，将建立一个有效的毛发重建实验，最终可能具有治疗意义。
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本文引用的文献
1
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Development. 2009 Aug;136(16):2815-23. doi: 10.1242/dev.038620. Epub 2009 Jul 15.
2
The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell-substratum adhesivity and cell motility.细胞外基质蛋白通过影响细胞与基质的粘附性和细胞运动性来增强真皮乳头细胞聚集。
Biomaterials. 2009 Oct;30(28):5031-40. doi: 10.1016/j.biomaterials.2009.05.065. Epub 2009 Jun 24.
3
Inhibition of glycogen synthase kinase-3 enhances the expression of alkaline phosphatase and insulin-like growth factor-1 in human primary dermal papilla cell culture and maintains mouse hair bulbs in organ culture.糖原合酶激酶-3的抑制增强了人原代毛乳头细胞培养物中碱性磷酸酶和胰岛素样生长因子-1的表达，并在器官培养中维持小鼠毛球。
Arch Dermatol Res. 2009 Jun;301(5):357-65. doi: 10.1007/s00403-009-0929-7. Epub 2009 Feb 24.
4
Cloned cells from the murine dermal papilla have hair-inducing ability.来自小鼠真皮乳头的克隆细胞具有诱导毛发的能力。
J Dermatol Sci. 2009 May;54(2):129-31. doi: 10.1016/j.jdermsci.2008.12.002. Epub 2009 Jan 15.
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J Clin Endocrinol Metab. 2009 Apr;94(4):1288-94. doi: 10.1210/jc.2008-1053. Epub 2009 Jan 13.
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10
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Nat Protoc. 2008;3(5):799-810. doi: 10.1038/nprot.2008.50.
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