Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
J Dermatol Sci. 2010 Jan;57(1):2-11. doi: 10.1016/j.jdermsci.2009.11.005.
Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells. The dermal compartment of the hair follicle consists of the dermal papilla and dermal sheath. Interactions between hair follicle epithelial and dermal cells are necessary for hair follicle morphogenesis during development and in hair reconstitution assays. Dermal papilla and dermal sheath cells express specific markers and possess distinctive morphology and behavior in culture. These cells can induce hair follicle differentiation in epithelial cells and are required in hair reconstitution assays either in the form of intact tissue, dissociated freshly prepared cells or cultured cells. This review will focus on hair follicle dermal cells since most therapeutic efforts to date have concentrated on this aspect of the hair follicle, with the idea that enriching hair-inductive dermal cell populations and expanding their number by culture while maintaining their properties, will establish an efficient hair reconstitution assay that could eventually have therapeutic implications.
毛囊干细胞位于上皮隆起处，是毛发生长期中毛囊持续再生的根源。隆起处的细胞位于真皮细胞组成的龛位中。毛囊的真皮部分包括毛囊乳头和毛囊鞘。在发育过程中和毛发重建实验中，毛囊上皮细胞与真皮细胞之间的相互作用对于毛囊形态发生是必需的。真皮乳头和毛囊鞘细胞表达特定的标记物，并在培养中具有独特的形态和行为。这些细胞可以诱导上皮细胞的毛囊分化，并且在毛发重建实验中无论是完整组织、新鲜分离的细胞还是培养细胞的形式都必不可少。本综述将重点关注毛囊真皮细胞，因为迄今为止大多数治疗方法都集中在毛囊的这一方面，其理念是通过培养丰富具有毛发诱导能力的真皮细胞群体并扩大其数量，同时保持其特性，将建立一个有效的毛发重建实验，最终可能具有治疗意义。
