Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, via Gabelli 63, 35121 Padova, Italy.
Bioorg Med Chem Lett. 2010 Feb 1;20(3):1202-4. doi: 10.1016/j.bmcl.2009.11.135. Epub 2009 Dec 4.
Simocyclinone D8 (SD8) is known to affect Gram-positive bacteria only. By testing SD8 against several clinical isolates, we showed that SD8 resulted very active against Gram-negative bacteria from clinical specimens, while it was shown inactive against laboratory strains. The activity against the former was in part due to enhanced drug entry. In addition, SD8 appears to share chromosome- and plasmid-mediated resistance mechanisms with fluoroquinolones.
西莫环酮 D8（SD8）已知仅对革兰氏阳性菌有影响。通过对几种临床分离株进行 SD8 测试，我们发现 SD8 对来自临床标本的革兰氏阴性菌非常有效，而对实验室菌株则无效。对前者的活性部分归因于增强的药物进入。此外，SD8 似乎与氟喹诺酮类药物具有染色体和质粒介导的耐药机制。
