Braillon A, Nguyen-Khac E, Merlin J, Dubois G, Gondry J, Capron D
Réseau hépato Picardie, CHU Nord, Amiens, France.
Gynecol Obstet Fertil. 2010 Jan;38(1):13-7. doi: 10.1016/j.gyobfe.2009.11.002. Epub 2009 Dec 21.
Screening for maternal hepatitis B surface antigen (HBsAg) is mandatory in France since 1992, however, no evaluation is available. We studied the traceability of HBsAg screening and its prevalence in pregnant women in Picardy for year 2006.
Traceability of HBsAg screening was studied in a sample of 1198 hospital case files, which were randomized and stratified for all the 20 clinics of the region (22,114 deliveries), both public and private. HBsAg prevalence was also studied using various registries (PMSI national database of medical acts performed during hospitalization, central pharmacies and obstetric theatres).
The traceability of the screening was lacking in 9.9% (range: 0-34.7%, depending on the maternity clinic). The prevalence of HBsAg during pregnancy was 1.8 per 1000 women (upper limit: 4.3 per 1000) from the case files sample. Registries examination showed large variations of HBsAg's prevalence from 0 to 12.0 per 1000 (mean: 2.9; CI 95%: 7 to 17) among the region.
HBsAg traceability during pregnancy must be improved. HBsAg prevalence largely varies among maternity clinics and is a significant issue which is underestimated in France.
自1992年起，法国强制要求对孕妇进行乙肝表面抗原（HBsAg）筛查，但尚无相关评估。我们研究了2006年皮卡第地区孕妇HBsAg筛查的可追溯性及其患病率。
在1198份医院病例档案样本中研究HBsAg筛查的可追溯性，这些病例档案针对该地区所有20家诊所（22114例分娩）进行了随机分层，涵盖公立和私立诊所。还使用各种登记处（住院期间医疗行为的全国性PMSI数据库、中心药房和产科手术室）研究了HBsAg患病率。
9.9%的筛查缺乏可追溯性（范围：0 - 34.7%，取决于产科诊所）。病例档案样本显示孕期HBsAg患病率为每1000名女性中有1.8例（上限：每1000名中有4.3例）。登记处检查显示该地区HBsAg患病率差异很大，从每1000名中有0例至12.0例（平均：2.9；95%置信区间：7至17）。
孕期HBsAg的可追溯性必须得到改善。HBsAg患病率在各产科诊所差异很大，这是一个在法国被低估的重要问题。
