FIGO 分级 1 子宫内膜腺癌伴复杂不典型增生背景的子宫内膜取样诊断与最终子宫切除病理。

Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology.

机构信息

Division of Gynecology, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Am J Obstet Gynecol. 2010 Mar;202(3):278.e1-6. doi: 10.1016/j.ajog.2009.10.882. Epub 2009 Dec 22.

DOI:10.1016/j.ajog.2009.10.882

PMID:20022581

Abstract

OBJECTIVE

The purpose of this study was to determine posthysterectomy pathologic findings in patients with a preoperative endometrial sampling diagnosis of International Federation of Gynecology and Obstetrics (FIGO) grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia (CAH).

STUDY DESIGN

We reviewed 1423 consecutive cases of endometrial cancer to identify cases with a preoperative endometrial biopsy that demonstrated FIGO grade 1 endometrial adenocarcinoma. Final uterine pathologic findings were grouped into low- and high-risk based on FIGO and Gynecologic Oncology Group criteria.

RESULTS

We identified 123 cases with a background of CAH and 367 cases without a background of CAH. FIGO grade in the hysterectomy specimen was more than FIGO grade 1 in 11 of 123 cases (8.9%) with a background of CAH, compared with 60 of 359 cases (16.7%) without a background of CAH (P = .04).

CONCLUSION

An endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of CAH is more likely to correlate with final posthysterectomy grade than a diagnosis not arising with a background of CAH.

摘要

目的

本研究旨在确定术前子宫内膜取样诊断为国际妇产科联合会（FIGO）分级 1 子宫内膜腺癌伴复杂不典型增生（CAH）背景的患者在子宫切除术后的病理发现。

研究设计

我们回顾了 1423 例连续的子宫内膜癌病例，以确定术前子宫内膜活检显示 FIGO 分级 1 子宫内膜腺癌的病例。最终的子宫病理结果根据 FIGO 和妇科肿瘤学组标准分为低危和高危组。

结果

我们在 123 例伴有 CAH 背景的病例和 367 例无 CAH 背景的病例中发现，在伴有 CAH 背景的 123 例病例中，有 11 例（8.9%）的子宫切除标本FIGO 分级高于 FIGO 分级 1 级，而在无 CAH 背景的 359 例病例中，有 60 例（16.7%）的子宫切除标本FIGO 分级高于 FIGO 分级 1 级（P=0.04）。