Withers B F, Ferguson P W, Swift D A
Division of Pharmacology and Toxicology, Northeast Louisiana University School of Pharmacy, Baton Rouge.
J La State Med Soc. 1991 Jan;143(1):33-40.
Cancer rates in Louisiana in particular, and the United States in general, especially as they relate to exposure to synthetic chemicals, have been a subject of great interest to the general public. Physicians are asked many difficult questions on this subject by their patients. This article provides an objective overview of cancer mortality rates and cancer risk assessment techniques with the intent of assisting physicians in providing knowledgeable responses to these questions. Prominent findings contained in this article include: (1) with the exception of lung cancer, due to consumption of tobacco products, cancer mortality rates are declining; (2) Louisiana ranks 16th among the 50 states in overall cancer mortality; (3) cancer risk assessment techniques used by the United States government are intentionally very conservative and overestimate real cancer risks, particularly for low level exposures; (4) the vast majority of cancers is related to individually controllable lifestyle factors; a small percentage is related to occupational or environmental exposures.
尤其是路易斯安那州以及整个美国的癌症发病率,特别是与接触合成化学物质相关的发病率,一直是公众极为关注的话题。患者会就这个问题向医生提出许多难题。本文提供了癌症死亡率和癌症风险评估技术的客观概述,旨在帮助医生对这些问题给出有见识的回答。本文包含的突出发现有:(1)除了因消费烟草制品导致的肺癌外,癌症死亡率正在下降;(2)在总体癌症死亡率方面,路易斯安那州在50个州中排名第16;(3)美国政府使用的癌症风险评估技术有意非常保守,高估了实际癌症风险,尤其是对于低水平接触;(4)绝大多数癌症与个人可控的生活方式因素有关;一小部分与职业或环境接触有关。