Atp4a-/- 小鼠的胃底腺囊肿类似于人类的胃底腺息肉。

Fundic gland cysts in Atp4a-/- mice mimic fundic gland polyps in humans.

机构信息

Department of Environemnt, University of Cincinnati Medical Center, Cincinnati, OH, USA

出版信息

In Vivo. 2009 Nov-Dec;23(6):979-81.

PMID:20023243

Abstract

BACKGROUND

Innumerable fundic gland polyps (FGPs) (that is massive FGP polyposis) may be found in the human stomach. Innumerable fundic gland cysts (FGCs) develop in mice lacking the gene Atp4a (Atp4a((-/-))), that encodes the enzyme ATPase. The aim was to monitor the evolution of FGCs in Atp4a((-/-)) mice.

MATERIALS AND METHODS

Six pairs (male-female) of Atp4a((-/-)) mice, 8, 12 and 20 months old, were investigated. Wild-type Atp4a((+/+)) mice were used as controls.

RESULTS

In Atp4a((-/-)) female mice, the mucosal thickness increased both at 8 months (943+/-72 mm) (p<0.02) and at 12 months (p<0.0008) and even further at 20 months (p<0.0001). The FGC area was 13.183+/-7.218 mm(2) at 12 months and 73.361+/-50.591 mm(2) at 20 months (p<0.0008). FGCs in Atp4a((-/-)) mice were lined by parietal cells, mucous pit-foveolar cells and chief cells, thus mimicking FGPs in humans.

CONCLUSION

Older female Atp4a((-/-)) mice developed innumerable FGCs, a phenomenon very similar to massive FGPs seen in humans. In the light of these similarities, the Atp4a((-/-)) mouse emerges as a suitable animal model to investigate the series of events taking place during the evolution of FGPs in humans.

摘要

背景

在人类的胃中可能会发现无数的胃底腺息肉（FGPs）（即大量的胃底腺息肉病）。在缺乏基因 Atp4a（Atp4a((-/-))）的小鼠中会发展出无数的胃底腺囊肿（FGCs），该基因编码 ATP 酶。目的是监测 Atp4a((-/-)) 小鼠中 FGCs 的演变。

材料和方法

研究了 6 对（雌雄各 3 对）年龄分别为 8、12 和 20 个月的 Atp4a((-/-)) 小鼠，同时使用野生型 Atp4a((+/+)) 小鼠作为对照。

结果

在 Atp4a((-/-)) 雌性小鼠中，黏膜厚度在 8 个月时（943+/-72mm）（p<0.02）和 12 个月时（p<0.0008）增加，在 20 个月时甚至进一步增加（p<0.0001）。在 12 个月时，FGC 面积为 13.183+/-7.218mm(2)，在 20 个月时为 73.361+/-50.591mm(2)（p<0.0008）。Atp4a((-/-)) 小鼠的 FGC 由壁细胞、粘蛋白陷窝细胞和主细胞排列，因此模仿了人类的 FGPs。