Department of Environemnt, University of Cincinnati Medical Center, Cincinnati, OH, USA
In Vivo. 2009 Nov-Dec;23(6):979-81.
Innumerable fundic gland polyps (FGPs) (that is massive FGP polyposis) may be found in the human stomach. Innumerable fundic gland cysts (FGCs) develop in mice lacking the gene Atp4a (Atp4a((-/-))), that encodes the enzyme ATPase. The aim was to monitor the evolution of FGCs in Atp4a((-/-)) mice.
Six pairs (male-female) of Atp4a((-/-)) mice, 8, 12 and 20 months old, were investigated. Wild-type Atp4a((+/+)) mice were used as controls.
In Atp4a((-/-)) female mice, the mucosal thickness increased both at 8 months (943+/-72 mm) (p<0.02) and at 12 months (p<0.0008) and even further at 20 months (p<0.0001). The FGC area was 13.183+/-7.218 mm(2) at 12 months and 73.361+/-50.591 mm(2) at 20 months (p<0.0008). FGCs in Atp4a((-/-)) mice were lined by parietal cells, mucous pit-foveolar cells and chief cells, thus mimicking FGPs in humans.
Older female Atp4a((-/-)) mice developed innumerable FGCs, a phenomenon very similar to massive FGPs seen in humans. In the light of these similarities, the Atp4a((-/-)) mouse emerges as a suitable animal model to investigate the series of events taking place during the evolution of FGPs in humans.
在人类的胃中可能会发现无数的胃底腺息肉(FGPs)(即大量的胃底腺息肉病)。在缺乏基因 Atp4a(Atp4a((-/-)))的小鼠中会发展出无数的胃底腺囊肿(FGCs),该基因编码 ATP 酶。目的是监测 Atp4a((-/-)) 小鼠中 FGCs 的演变。
研究了 6 对(雌雄各 3 对)年龄分别为 8、12 和 20 个月的 Atp4a((-/-)) 小鼠,同时使用野生型 Atp4a((+/+)) 小鼠作为对照。
在 Atp4a((-/-)) 雌性小鼠中,黏膜厚度在 8 个月时(943+/-72mm)(p<0.02)和 12 个月时(p<0.0008)增加,在 20 个月时甚至进一步增加(p<0.0001)。在 12 个月时,FGC 面积为 13.183+/-7.218mm(2),在 20 个月时为 73.361+/-50.591mm(2)(p<0.0008)。Atp4a((-/-)) 小鼠的 FGC 由壁细胞、粘蛋白陷窝细胞和主细胞排列,因此模仿了人类的 FGPs。
年长的雌性 Atp4a((-/-)) 小鼠会发展出无数的 FGCs,这一现象与人类中所见的大量 FGPs 非常相似。鉴于这些相似之处,Atp4a((-/-)) 小鼠成为研究人类 FGPs 演变过程中发生的一系列事件的合适动物模型。