Yildirim Kadir, Deniz Orhan, Gureser Gurhan, Karatay Saliha, Ugur Mahir, Erdal Akin, Senel Kazim
Department of Physical Medicine and Rehabilitation, School of Medicine, Ataturk University, Erzurum, Turkey.
J Back Musculoskelet Rehabil. 2009;22(1):17-20. doi: 10.3233/BMR-2009-0210.
The purpose of this, open-label, non-comparative study, was to evaluate the efficacy on quality of life and the efficacy of gabapentin monotherapy in patients with chronic radiculopathy.
Thirty-five patients with radicular pain and diagnosed as L4, L5 or S1 radiculopathy were treated with oral gabapentin from a total of 300 mg per day once up to a total of 1800 mg per day divided in 3 doses for eight-week trial period. Quality of life, functional disability and psychological mood of the patients were assessed using the Nottingham Healthy Profile (NHP), Oswestry Low Back Pain Disability Questionnaire (ODQ) and Beck Depression Inventory (BDI).
Of the patients (n = 35), 25 were females and 10 were males (mean age: 41.8 +/- 10.4, range: 24-60 years); mean radiculopathy duration was 16.4 +/- 14.2 months (range: 3-48 months). The pain intensity at rest, quality of life, functional disability and depression scores were determined significantly improved after treatment and 4 months compared to baseline scores (p < 0.001). 1.5 points compared to baseline for at pain rest and 15 points improvement on the ODQ were obtained.
Gabapentin may provide benefits in terms of alleviation of pain and overall quality of life in patients with chronic radiculopathy.
本开放性、非对照研究旨在评估加巴喷丁单一疗法对慢性神经根病患者生活质量的疗效。
35例诊断为L4、L5或S1神经根病且有神经根性疼痛的患者，在为期8周的试验期内口服加巴喷丁，初始剂量为每日300mg，单次服用，最大剂量为每日1800mg，分3次服用。使用诺丁汉健康量表（NHP）、Oswestry下腰痛功能障碍问卷（ODQ）和贝克抑郁量表（BDI）评估患者的生活质量、功能障碍和心理情绪状态。
35例患者中，女性25例，男性10例（平均年龄：41.8±10.4岁，范围：24 - 60岁）；平均神经根病病程为16.4±14.2个月（范围：3 - 48个月）。与基线评分相比，治疗后及治疗4个月时静息时疼痛强度、生活质量、功能障碍和抑郁评分均有显著改善（p < 0.001）。静息时疼痛较基线改善1.5分，ODQ改善15分。
加巴喷丁在缓解慢性神经根病患者疼痛及改善总体生活质量方面可能有益。
