Laboratory of Regenerative Medicine and Pharmacobiology and Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Integr Biol (Camb). 2009 Jul;1(7):446-51. doi: 10.1039/b907627c. Epub 2009 May 28.
Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circulating carrier. As such, the carrier is enabling the biomolecule or the bioactive to carry out its designed biological function. Due to their small size nanoparticles may also induce perturbations of biological systems different from any other biomaterials, therefore opening up new biomedical applications as well as raising concerns about adverse effects.
高分子纳米颗粒技术已经从药物载体设计发展到先进的多功能高分子结构。它们能够在时空控制下进行药物输送和生物活性物质的释放，而不仅仅是通过长循环载体进行被动释放。因此，载体使生物分子或生物活性物质能够发挥其设计的生物学功能。由于其粒径较小，纳米颗粒也可能引起不同于任何其他生物材料的生物系统的干扰，因此开辟了新的生物医学应用，但也引起了对不良反应的关注。
