Winter Patrick M, Cai Kejia, Caruthers Shelton D, Wickline Samuel A, Lanza Gregory M
Medicine and Biomedical Engineering, C-TRAIN Group, St. Louis, MO 63108, USA.
Expert Rev Med Devices. 2007 Mar;4(2):137-45. doi: 10.1586/17434440.4.2.137.
Perfluorocarbon (PFC) nanoparticles can serve as a platform technology for molecular imaging and targeted drug-delivery applications. These nanoparticles are approximately 250 nm in diameter and are encapsulated in a phospholipid shell, which provides an ideal surface for the incorporation of targeting ligands, imaging agents and drugs. For molecular imaging, PFC nanoparticles can carry very large payloads of gadolinium to detect pathological biomarkers with magnetic resonance imaging. A variety of different epitopes, including alpha(v)beta(3)-integrin, tissue factor and fibrin, have been imaged using nanoparticles formulated with appropriate antibodies or peptidomimentics as targeting ligands. Lipophilic drugs can also be incorporated into the outer lipid shell of nanoparticles for targeted delivery. Upon binding to the target cell, the drug is exchanged from the particle surfactant monolayer to the cell membrane through a novel process called 'contact facilitated drug delivery'. By combining targeted molecular imaging and localized drug delivery, PFC nanoparticles provide diagnosis and therapy with a single agent.
全氟碳（PFC）纳米颗粒可作为分子成像和靶向药物递送应用的平台技术。这些纳米颗粒直径约为250纳米，包裹在磷脂壳中，这为掺入靶向配体、成像剂和药物提供了理想的表面。对于分子成像，PFC纳米颗粒可携带大量的钆以通过磁共振成像检测病理生物标志物。使用以适当抗体或肽模拟物作为靶向配体配制的纳米颗粒，已对包括α(v)β(3)-整合素、组织因子和纤维蛋白在内的多种不同表位进行了成像。亲脂性药物也可掺入纳米颗粒的外层脂质壳中用于靶向递送。与靶细胞结合后，药物通过一种称为“接触促进药物递送”的新过程从颗粒表面活性剂单层交换到细胞膜。通过结合靶向分子成像和局部药物递送，PFC纳米颗粒用单一药剂实现诊断和治疗。
