含吡唑啉酮和/或吡唑配体的钌(III)配合物的双重抗血管生成和细胞毒性作用。
Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands.
机构信息
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
出版信息
Dalton Trans. 2009 Dec 28(48):10712-6. doi: 10.1039/b912236b. Epub 2009 Sep 14.
An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 microM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands Ru(pz)(4)X(2) exhibit dual anti-angiogenic and cytotoxic properties.
一种含有吡唑啉和吡唑啉配体的氧桥联二钌（III）配合物对抗坏血酸还原具有稳定性，在 10 μM 浓度下诱导 HeLa 细胞凋亡（60%，48 小时），并在亚细胞毒性浓度下表现出有希望的抗血管生成活性。其他含有吡唑啉配体的单核钌（III）配合物[Ru（pz）（4）X（2）]（+）具有双重抗血管生成和细胞毒性特性。
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