Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 Leiden, The Netherlands.
Dalton Trans. 2009 Dec 28(48):10727-30. doi: 10.1039/b909520a. Epub 2009 Aug 17.
Tris(o-anisyl)phosphane was reacted with ruthenium(III) chloride forming a novel Ru(III) complex of formula [Ru(PAn(3))(P(An)(phenolate)(2))Cl] containing a tridentate dianionic P,O,O-ligand and a bidentate neutral P,O ligand. The tridentate ligand was formed by elimination of two methyl groups from the starting ligand in the reaction with the ruthenium salt. The molecular structure was determined by single crystal X-ray diffraction analysis. The compound shows a high cytotoxic activity in ovarian cancer cell lines comparable with cisplatin and overcoming cisplatin-resistance.
三（邻甲氧基苯基）膦与氯化钌反应，形成了一种新型的钌（III）配合物，化学式为[Ru(PAn(3))(P(An)(苯并菲酚)(2))Cl]，其中含有一个三齿阴离子 P,O,O-配体和一个二齿中性 P,O 配体。三齿配体是在与钌盐反应时，从起始配体中消除两个甲基基团形成的。该化合物的分子结构通过单晶 X 射线衍射分析确定。该化合物在卵巢癌细胞系中表现出与顺铂相当的高细胞毒性活性，并克服了顺铂耐药性。
