Department of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Dalton Trans. 2009 Dec 28(48):10914-25. doi: 10.1039/b918902e. Epub 2009 Nov 16.
A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.
已经合成、分离和表征了一些新型钌化合物，它们对多种不同的人类肿瘤细胞系表现出优异的细胞毒性，包括一个明确的顺铂耐药细胞系和结肠癌细胞系。向钌分子中添加疏水性基团对细胞毒性值有积极影响。有证据表明，在将一种钌化合物与 46 个碱基对的寡核苷酸双链体孵育并随后进行核酸酶处理后，钌与鸟嘌呤残基结合。
