Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045-7582, USA.
Nat Prod Rep. 2010 Jan;27(1):23-31. doi: 10.1039/b912196j. Epub 2009 Oct 26.
Much of our knowledge in neuroscience was discovered through the study of mind-altering natural products. However, although much has been learned about human physiology and basic biological processes, the underlying causes of CNS disorders and other disease states are still elusive. Based on its main past successes, the continued study of mind-altering compounds promises to yield novel agents that may be developed into medications and to identify new targets for the treatment of diseases. This Highlight describes the history of investigations into several classes of mind-altering natural products and relates recent and potential therapeutic uses for these agents.
我们在神经科学领域的许多知识都是通过研究改变心智的天然产物发现的。然而，尽管我们已经了解了很多关于人类生理学和基本生物过程的知识，但中枢神经系统疾病和其他疾病状态的根本原因仍然难以捉摸。基于其过去的主要成功经验，对改变心智的化合物的持续研究有望产生新的药物，并为疾病的治疗确定新的靶点。本要点描述了对几类改变心智的天然产物的研究历史，并阐述了这些药物的近期和潜在治疗用途。
