小分子诱导的双链和三链 DNA 导向的化学反应控制。

Small molecule induced control in duplex and triplex DNA-directed chemical reactions.

机构信息

Danish Research Foundation: Centre for DNA Nanotechnology at the Interdisciplinary Nanoscience Center and the Department of Chemistry, AarhusUniversity, Langelandsgade 140, 8000 Aarhus C, Denmark.

出版信息

Org Biomol Chem. 2010 Jan 7;8(1):50-2. doi: 10.1039/b919387a. Epub 2009 Nov 9.

DOI:10.1039/b919387a

PMID:20024130

Abstract

Triplex DNA binders can effectively control copper-catalysed alkyne-azide click reactions in DNA architecture, such that either duplex or triplex DNA directed reactions of terminally attached azides and alkynes occur, in the absence or presence of triplex DNA binder, respectively.

摘要

三链 DNA 结合剂可有效控制铜催化的炔基-叠氮点击反应在 DNA 结构中，使得末端连接的叠氮化物和炔烃的双链或三链 DNA 导向反应分别在不存在或存在三链 DNA 结合剂的情况下发生。