Delahunt B, Ribas J L, Nacey J N, Bethwaite P B
Department of Pathology, Wellington School of Medicine, University of Otago, New Zealand.
J Pathol. 1991 Jan;163(1):31-7. doi: 10.1002/path.1711630107.
The prognostic significance of nucleolar organizer regions (NORs) in renal cell carcinoma (RCC) was evaluated. NORs were quantified in a series of 182 cases of RCC using the silver-colloid method. The cases were staged according to Robson's method (48 stage I, 26 stage II, 33 stage III, 75 stage IV) and mean NOR numbers for each tumour were correlated with survival over a 5-year period. Localized tumours (stages I and II) with low NOR numbers had an almost 100 per cent 5-year survival. Those patients with clinical evidence of metastases at presentation showed a high mortality, although those with low numbers of NORs had a significantly increased disease-free interval. Statistical analysis using the log rank test indicated NORs to be a significant predictor of survival over the whole series (P = 0.0001) and within each of Robson's stages (P = 0.0008 stage I, P = 0.0154 stage II, P = 0.0009 stage III, P = 0.0001 stage IV). Analysis of data using Cox's proportional hazard model showed mean NOR numbers to be independent of stage as a predictor of survival.
评估了肾细胞癌（RCC）中核仁组织区（NORs）的预后意义。采用银胶体法对182例RCC病例的NORs进行定量分析。根据罗布森方法对病例进行分期（I期48例，II期26例，III期33例，IV期75例），并将每个肿瘤的平均NOR数量与5年生存率相关联。NOR数量低的局限性肿瘤（I期和II期）5年生存率几乎为100%。那些初诊时有转移临床证据的患者死亡率很高，尽管NOR数量低的患者无病生存期显著延长。使用对数秩检验的统计分析表明，NORs是整个系列（P = 0.0001）以及罗布森各分期（I期P = 0.0008，II期P = 0.0154，III期P = 0.0009，IV期P = 0.0001）生存的显著预测指标。使用考克斯比例风险模型对数据进行分析表明，平均NOR数量作为生存预测指标独立于分期。
