一种酶促途径合成 5-脱氧-5-[18F]氟-D-核糖，一种用于 PET 成像的[18F]氟代糖。
An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging.
机构信息
University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UKKY16 9ST.
出版信息
Chem Commun (Camb). 2010 Jan 7;46(1):139-41. doi: 10.1039/b919364b. Epub 2009 Nov 10.
DOI:10.1039/b919364b
PMID:20024319
Abstract
An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel [(18)F]-fluorinated sugar suitable for positron emission tomography (PET) applications.
摘要
描述了一种高效的两步、一锅、生物转化方法，涉及氟酶，用于合成 5-脱氧-5-[(18)F]氟代核糖，这是一种新型的适用于正电子发射断层扫描（PET）应用的[(18)F]氟代糖。
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