largamide H 的全合成。

Total synthesis of largamide H.

机构信息

Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, China.

出版信息

Chem Commun (Camb). 2010 Jan 7;46(1):153-5. doi: 10.1039/b921000h. Epub 2009 Nov 16.

DOI:10.1039/b921000h

PMID:20024324

Abstract

Total synthesis of largamide H has been completed, utilising the oxidative elimination reaction of enantiomerically pure 2-amino-3-(phenylselenyl)butanoic acid residues to stereospecifically install both (Z)- and (E)-2,3-dehydro-2-aminobutanoic moieties.

摘要

largamide H 的全合成已经完成，利用对映纯 2-氨基-3-（苯硒基）丁酸残基的氧化消除反应，立体特异性地安装了(Z)-和(E)-2,3-去氢-2-氨基丁酸部分。